Leading Teachers

Introduction：

Education：2008-2015  Zhejiang University  Ph.D.1999-2001  Zhejiang University  M.D.1994-1999  Zhejiang University  B.S. Expertise:Obstetrics and Gynecology Research Interests:Reproductive medicine and reproductive genetics Research Narrative:Dr. Xu is the director of education office of Women’s Hospital, School of Medicine, Zhejiang University. He has been engaged in clinical, scientific research and teaching of obstetrics and gynecology for more than ten years, and is proficient in the diagnosis and treatment of reproductive genetics, irregular menstruation, infertility, fertility preservation and so on. Publication:Epigenetic inheritanceof paternally expressed imprinted genes in the testes of ICSI mice. Curr Pharm Des 2014 ;20 (11): 1764-71.Detection of DNA damage caused by cryopreservation using a modified SCGE in large yellow croaker, Pseudosciaenacrocea. Acta Biol Hung. 2014 ,65(4):405-13. Improvement of single-cell gel electrophoresis (SCGE) alkaline comet assay. Aquat Biol.2013,18:293-295. Personal Homepage:https://person.zju.edu.cn/en/xxr

Introduction：

Education：11/2017-05/2018  Brigham and Women’s Hospital, Harvard Medical School  Visiting Scholar09/2016-12/2016  University of California, Los Angeles (UCLA)        Visiting Scholar0/92011-12/2011  Southampton University Hospital and Poole Hospital    Visiting Scholar2007-2011    Zhejiang University School of Medicine   Doctor Degree1999-2001    Zhejiang University School of Medicine   Master Degree.1994-1999   Zhejiang University School of Medicine   Bachelor Degree in Clinical Medicine Expertise:Reproductive Endocrinology Research Interests:1. Safety and improvement of assisted reproductive technology2. Reproductive aging and reproductive genetics Research Narrative:As an expert in reproductive medicine, Dr. Zhang Dan has dedicated herself to fundamental, clinical and translational study on reproductive aging and reproductive safety for over 20 years. She has published over 50 papers in SCI journals including Molecular Aspects of Medicine, Aging Cell, Human Genetics, and serves as the first/co-first/corresponding/co-corresponding author in 25 of them. She is in charge of six projects of National Natural Science Foundation of China, one sub-project of National Key Research and Development Program of China, one project of Zhejiang Provincial Natural Science Foundation for Distinguished Young Scientists, seven provincial-level projects, and serves as a key investigator in two projects of National Key Research and Development Program of China. Publication:1. Li JY, Liu YF, Xu HY, Zhang JY, Lv PP, Liu ME, Ying YY, Qian YQ, Li K, Li C, Huang Y, Xu GF, Ding GL, Mao YC, Xu CM, Liu XM, Sheng JZ, Zhang D, Huang HF. Basonuclin 1 deficiency causes testicular premature aging: BNC1 cooperates with TAF7L to regulate spermatogenesis.J Mol Cell Biol. 2019 May 8. doi: 10.1093/jmcb/mjz035. [Epub ahead of print].2.Zhang W, Chen Z, Yin Q, Zhang D, Racowsky C, Zhang Y. Maternal-biased H3K27me3 correlates with paternal-specific gene expression in the human morula. Genes Dev. 2019 Feb. doi:10.1101/gad.323105.1183. Guo J, Lv N, Tang J, Zhang X, Peng LH, Du XF, Li S, Luo Q, Zhang D, Chen GD. Associations of blood metal exposure with thyroid hormones in Chinese pregnant women: A cross-sectional study. Environ Int. 2018 Dec;121(Pt 2):1185-1192.4.  Huang Y, Guo J, Lv N, Li S, Wu YQ, Bai RP, Shen J, Chen GD, Zhang D#. Associations of urinary polycyclic aromatic hydrocarbons with age at natural menopause in U.S. women aged 35-65, NHANES 2003-2012. Environ Pollut, 2018;243(Pt B):1878-86.5.  Zhang D*, Liu YF*, Zhang Z*, Lv PP*, Liu Y, Li JY, Wu YQ, Zhang RJ, Huang Y, Xu GF, Qian YQ, Qian YL, Chen SC, Xu CM, Shen J, Zhu LL, Chen K, Zhu B, Ye XQ, Mao YC, Bo XS, Zhou CY, Wang TT, Chen DF, Yang WJ, Tan YJ, Song Y, Zhou DZ, Sheng JZ, Gao HJ, Zhu YM, Li MG, Wu LP, He L, Huang HF. Basonuclin 1 deficiency is a cause of primary ovarian insufficiency. Hum Mol Genet, 2018;27(21):3787-800.6. Sun X, Guo JH, Zhang D, Chen JJ, Lin WY, Huang Y, Chen H, Huang WQ, Liu Y, Tsang LL, Yu MK, Chung YW, Jiang X, Huang H, Chan HC, Ruan YC. Activation of the epithelial sodium channel (ENaC) leads to cytokine profile shift to pro-inflammatory in labor. EMBO Mol Med. 2018;10(10).7. Huang Y, Li JY, Zhang F, Liu YF, Xu GF, Guo J, Zhang RJ, Wu YQ, Liu J, Chen K, Zhao W, Wu W, Hu YJ, Chen GD, Zhang D#. Factors affecting the live-birth rate in women with diminished ovarian reserve undergoing IVF-ET. Arch Gynecol Obstet. 2018;298(5):1017-1027.8.Li K, Li R, Ni Y, Sun PB, Liu Y, Zhang D, Huang HF. Novel distance-progesterone-combined selection approach improves human sperm quality. J Transl Med. 2018 Jul 20;16(1):203.9. Zhao W, Liu YF, Xu P, Wu YQ, Chen K, Guo XY, Zhang F, Huang Y, Zhu LL, Zhang RJ, Zhang D#. Effects of estradiol for luteal phase support in fresh embryo transfer cycles: A retrospective cohort study. Clinical Endocrinology(Oxf). 2018 May 12. doi: 10.1111/cen.13740.10. Chen XJ, Chen F, Lv PP, Zhang D, Ding GL, Hu XL, Feng C, Sheng JZ, Huang HF. Maternal high estradiol exposure alters CDKN1C and IGF2 expression in human placenta. Placenta. 2018; 61:72-79.11.Liu F, Liu YF, Liu J, Huang Y, Xu GF, Cai J, Chen Y, Wu YQ, Ying YY, Zhang RJ, Zhang D#. Effect of different anesthesia on the reproductive and obstetric outcomes of heterotopic pregnancies. International Journal of Obstetric Anesthesia. 2018（34）, 73–78. 12. Shi Y, Sun Y, Hao C, Zhang H, Wei D, Zhang Y, Zhu Y, Deng X, Qi X, Li H, Ma X, Ren H, Wang Y, Zhang D, Wang B, Liu F, Wu Q, Wang Z, Bai H, Li Y, Zhou Y, Sun M, Liu H, Li J, Zhang L, Chen X, Zhang S, Sun X, Legro RS, Chen ZJ. Transfer of Fresh versus Frozen Embryos in Ovulatory Women. N Engl J Med. 2018 Jan 11;378(2):126-136.13. Xu GF, Zhou CL, Xiong YM, Li JY, Yu TT, Tian S, Lin XH, Liao Y, Lv Y, Zhang FH, Liu ZW, Shi YY, Shen Y, Sha J, Zhang D, Zhu YM, Sheng JZ, Huang HF. Reduced Intellectual Ability in Offspring of Ovarian Hyperstimulation Syndrome: A Cohort Study. EBioMedicine. 2017;20:263-7.14. Xu GF，Liao Y，Li JY，Liu YF，Huang Y，Wu YQ，Liu J，Lv PP，Zhang RJ，Zhang D#. Ovarian stimulation perturbs methylation status of placental imprinting genes and reduces blood pressure in the second generation offspring，European Journal of Obstetrics & Gynecology and Reproductive Biology，2017.2.22，211（2017）：140~145.15. Sun YX*, Zhang YX*, Zhang D*, Xu CM, Chen SC, Zhang JY, Ruan YC, Chen F, Zhang RJ, Qian YQ, Liu YF, Jin LY, Yu TT, Xu HY, Luo YQ, Liu XM, Sun F, Sheng JZ, Huang HF. XCI-escaping gene KDM5C contributes to ovarian development via downregulating miR-320a. Hum Genet. 2017, 136(2):1-13.16. Lv PP, Tian S, Feng C, Li JY, Yu DQ, Jin L, Shen Y, Yu TT, Meng Y, Ding GL, Jin M, Chen XJ, Sheng JZ, Zhang D#, Huang HF#. Maternal High Estradiol Exposure is Associated with Elevated Thyroxine and Pax8 in Mouse Offspring. Sci Rep. 2016 Nov 9;6:36805.17. Zhu L, Zhang Y, Liu Y, Zhang R, Wu Y, Huang Y, Liu F, Li M, Sun S, Xing L, Zhu Y, Chen Y, Xu L, Zhou L, Huang H#, Zhang D#.Maternal and Live-birth Outcomes of Pregnancies following Assisted Reproductive Technology: A Retrospective Cohort Study.Sci Rep. 2016 Oct 20;6:35141.18.Zhang D*#, Xu GF*, Zhang RJ, Zhu YM, Gao HJ, Zhou C, Sheng JZ, Huang HF#. Decreased expression of aquaporin 2 is associated with impaired endometrial receptivity in controlled ovarian stimulation. ReprodFertil Dev. 2016, 28(4): 499-506.19. Song Y, Wang ES, Xing LL, Shi S, Qu F, Zhang D, Li JY, Shu J, Meng Y, Sheng JZ, Zhou JH, Huang HF. Follicle-Stimulating Hormone Induces Postmenopausal Dyslipidemia Through Inhibiting Hepatic Cholesterol Metabolism. J Clin Endocrinol Metab. 2016; 101: 254–263.20. Liu AX, Zhang D, Zhu YM, Gao HJ, Jiang JY, Hu XL, Lv PP, Leung PC, Huang HF. Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line. CurrMol Med. 2016;16(3):299-311. Personal Homepage:https://person.zju.edu.cn/en/zd_zju_en#0

Introduction：

朱小明，男，主任医师，副教授，硕士生导师。 1982年12月南通大学医学院医学系本科毕业，获医学学士学位；1988 年8月山东大学医学院妇产科学硕士研究生毕业，获医学硕士学位；2006 年6月浙江大学医学院妇产科学博士研究生毕业，获医学博士学位。一直从事妇产科学临床、教学和科研工作。在生殖内分泌临床、辅助生殖技术和计划生育方面有专长。研究方向：1. 生殖衰老与辅助生殖临床；2. 辅助生殖技术的子代安全性；3.自体胚胎干细胞的创建技术。先后参编专著一部，教材二部，公开发表论文20 余篇，其中SCI 收录12 篇。有主持或参与国家和省部级科研项目经历。现为教育部普通高校五年制医学本科《妇产科学》教材编委，教育部主管《现代妇产科进展》杂志编委。先后获省级普通高校优秀青年骨干教师和校级教学成果一等奖表彰各1次。2000年获国家留学基金委员会资助，以访问学者身份赴加拿大British Columbia 大学进修学习辅助生殖技术一年。